Scripps Laboratories is a world-leading producer and supplier of purified human Liver Ferritin and Spleen Ferritin. Various preparations are available and are listed below. Please visit each product page to view individual product specifications.
Ferritin is a water-soluble, iron storage protein found in most animal cells. Its spherical structure is composed of 24 subunits and contains a 7-nm cavity with a ferric oxyhydroxide crystalline core that is capable of storing approximately 4500 iron atoms. Iron passes in and out of the ferritin cavity through 0.7-1.0 nm pores in the outer shell. Up to 25 ferritin isoforms are thought to exist, composed of various combinations of the two primary subunits, H and L, which have molecular weights of 21,000 and 19,000, respectively. Ferritin rich in the H subunit is found in heart muscle, red blood cells, lymphocytes, and monocytes, while that rich in the L subunit is found in the liver, spleen, and placenta. Ferritins composed of a higher proportion of H subunits are more acidic (pI as low as 4.8) than the isoforms containing a higher proportion of L subunits (pI 5.3-5.8) Human serum ferritin is primarily composed of the L subunit, which also corresponds with a lower iron content. Ferritin isolated from the liver and spleen contain > 12% iron by weight.
Ferritin is the body's primary iron source for hemoglobin synthesis; only hemoglobin itself accounts for more of the body's total iron content. When serum iron levels decrease below normal levels, ferritin readily releases its iron stores for use. Serum levels of ferritin are known to closely parallel tissue ferritin levels and are, therefore, indicative of body iron content. As such, clinical tests for ferritin serum levels are used to detect and manage iron-related disorders, such as iron deficiency anemia and iron overload. In addition, high levels of serum ferritin have been associated with malignant disease and tissue damage.
Human Ferritin is isolated from either spleen or liver. Regardless of source, ferritin is supplied as a liquid in 10mM Tris, 150mM Sodium Chloride, 0.1% Sodium Azide, pH 8.0 ± 0.1. Protein is determined by immunoassay.
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