Cathepsin D is an estrogen-regulated, lysosomal acidic protease associated with tissue breakdown. Elevated levels of Cathepsin D are indicative of breast cancer recurrence in both node-negative and node-positive disease. Over-expression of Cathepsin D is also linked to tumorigenesis in prostate cancer and to aggressive forms of colorectal cancer and lung adenocarcinoma. In addition, Cathepsin D is associated with amyloid formation in Alzheimer's plaques as is possibly linked to lung tissue damage in cigarette smokers.
This preparation of Cathepsin D is isolated from human liver and is supplied as a powder, lyophilized from 2.5mM Sodium Phosphate, pH 6.5 ± 0.1. Protein is determined prior to lyophilization using the Bradford method. One unit of the enzyme will produce an increase in absorbance of 1.0 per ml per hour, measured at 280nm, pH 3.3, 37°C, using bovine hemoglobin as the substrate.
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