General Product Information: Thyroglobulin is isolated from human thyroid glands and is supplied lyophilized. Prior to lyophilization the protein is passed through a Protein A column to decrease IgG levels. Protein is determined prior to lyophilization by measuring the absorbance at 280nm (Emg/ml = 1.04).
Catalog No. T0714 (Part No. 90349)
Purity: ≥ 96% by Serum Protein
Electrophoresis or Polyacrylamide Gel Electrophoresis.
Sample Certificate, MS Word
Thyroglobulin is a large globular glycoprotein (approximate MW = 660,000)
produced by follicular cells of the thyroid gland. Post-transcriptional iodination and proteolysis of thyroglobulin
produces the two iodine containing hormones of the thyroid, triiodothyronine and thyroxine. The rate of
synthesis of thyroglobulin in the thyroid is regulated by follicle stimulating hormone of the anterior pituitary
gland.
Serum levels of thyroglobulin are useful in the follow-up of differentiated thyroid carcinoma, Graves disease,
and several other physiological and pathophysiological conditions.