General Product Information: Cathepsin D is isolated from human liver and is supplied as a powder, lyophilized from 2.5mM Sodium Phosphate, pH 6.5 ± 0.1. Protein is determined prior to lyophilization using the Bradford method. One unit of the enzyme will produce an increase in absorbance of 1.0 per ml per hour, measured at 280nm, pH 3.3, 37°C, using bovine hemoglobin as the substrate.
Catalog No. C2414 (Part No. 90103)
Purity: determined by SDS-PAGE and agarose gel electrophoresis.
Protein Content: determined by the Bradford method prior to lyophilization
Activity: ≥ 300 units/mg
Sample Certificate, MS Word
Cathepsin D is an estrogen-regulated, lysosomal acidic protease associated with tissue breakdown. Elevated levels of Cathepsin D are indicative of breast cancer recurrence in both node-negative and node-positive diesease. In addition, Cathepsin D is associated with amyloid formation in Alzheimer's plaques as is possibly linked to lung tissue damage in cigarette smokers.