General Product Information: Scripps Laboratories manufactures affinity purified goat antibodies to whole molecule hCG, α-hCG, and β-hCG. These antibodies are further purified by gel filtration to remove aggregates and potential hCG contamination. The antibodies against whole hCG and β -hCG have both been used in FDA-cleared pregancy tests. The β-specific antibody has been paired with Scripps monoclonal antibody (MC097, clone BC001) in a diagnostic test, with esentially no cross-reactivity with LH.
Catalog No. GC079 (Part No. 90058) - Goat antibody to whole molecule hCG
Affinity purified; reacts with intact hCG and free α- and β-hCG. Sample Certificate, PDF
Catalog No. GC089 (Part No. 90121) - Goat antibody to α-hCG
Affinity purified; reacts with intact hCG and free α-hCG. Sample Certificate, PDF
Catalog No. GC099 (Part No. 90062) - Goat antibody to β-hCG
Affinity purified; reacts with intact hCG and free β-hCG. Sample Certificate, PDF
Immunoassays for hCG serum levels are useful in the detection and/or verification of normal pregnancy, as elevated levels of hCG are reportedly detectable as early as seven days after conception. In addition,
low levels of serum hCG may help diagnose ectopic pregnancy, while elevated levels of serum hCG have been reported in patients with trophoblastic disease, choriocarcinoma, and various other types of cancer.
hCG can be cleaved to yield two dissimilar subunits, α-hCG and β-hCG. The α-subunit (approximate molecular weight of 14,500 Daltons) is virtually identical to the α-subunits
of the related pituitary hormones, Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), and Thyroid Stimulating Hormone (TSH). The biological activity of hCG is dependent on the distinct make-up
of the β-subunit (approximate molecular weight of 22,200 Daltons), which differs in amino acid sequence from the β-subunits of FSH, LH, and TSH.