Sex Hormone Binding Globulin (SHBG)
General Product Information
Sex Hormone Binding Globulin is purified from human serum. It is a liquid preparation supplied in 20mM Tris, 10% glycerol, pH 7.4. This preparation is >95% pure by SDS-PAGE and is stripped of dihydrotestosterone.
Sex Hormone Binding Globulin (SHBG), or Testosterone-estradiol Binding Globulin (TeBG), is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone, and estradiol. SHBG enhances the exchange of these steroids in central tissues. Because only free steroids can act biologically, it is often necessary to account for SHBG-bound steroids. Estrogens have the effect of increasing SHBG serum concentrations and androgens decrease the serum concentrations of SHBG. This phenomenon is helpful in studying sex- and age-related biological changes.
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