Prolactin, Human (hPRL)
Scripps Laboratories is a world-leading producer and supplier of purified human Prolactin. Various purities, plus native and recombinant preparations, are available and are listed below. Please visit each product page to view individual product specifications.
Prolactin is secreted by the anterior pituitary gland and, like growth hormone, is a non-glycosylated single polypeptide chain. Its primary function is the development and maintenance of lactation. Serum levels of prolactin elevate after approximately the eighth week of pregnancy and continue to rise until term.
Elevated serum levels of prolactin are associated with infertility in men and women, male impotence, and primary hypothyroidism. In addition, abnormal prolactin serum levels in women have been associated with several clinical conditions: galactorrhea, anovulation with amenorrhea, hypoestrogenism, and hyperprolactinaemia. As such, immunoassays for prolactin serum levels are useful in the detection and monitoring of these disorders.
Native prolactin is isolated from human pituitary glands, while the recombinant form is expressed in E. coli, which contains a clone of the human prolactin gene. Native prolactin and the recombinant form are both provided as a powder, lyophilized from ammonium bicarbonate. Protein content is determined using the Bradford method (BSA standard).
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