Intrinsic Factor, Porcine
General Product Information
Intrinsic Factor (I1024) is purified from porcine stomach extracts and is supplied in a liquid form in distilled water. The material is assayed at >98% intrinsic factor based on vitamin B12 binding assays using cobinamide and anti-intrinsic factor antibodies.
Intrinsic Factor is synthesized by the parietal cells of the stomach and is a glycoprotein containing approximately 15% carbohydrate. It is composed of two identical subunits each with one vitamin B12 binding site. Intrinsic Factor is one of four important secretions of the gastric mucosa along with hydrochloric acid, pepsin, and mucus. It is required for the absorption of vitamin B12 in the ileum. Vitamin B12 deficiency leads to pernicious anemia which is caused by malabsorption due to defective transport systems, parasitic infections, or surgical removal of the stomach.
Intrinsic Factor is useful in the development of assays to determine serum B12 levels. It is most effective when used in a highly purified state to minimize the effects of R proteins which non-specifically bind vitamin B12.
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