C-Reactive Protein

General Product Information 

C-Reactive Protein is isolated from human plasma or pleural fluid and is supplied as a liquid in 20mM Tris, 280 mM Sodium Chloride, 5mM Calcium Chloride, 0.1% Sodium Azide, pH 8.0 ± 0.1. Protein concentration is determined by nephelometry or by A280 using an extinction coefficient of 1.7 (Emg/ml = 1.7).

C-Reactive Protein (CRP) belongs to the β-globulin family of plasma proteins and derives its name from its ability to precipitate a group C polysaccharide of pneumococcus in the presence of Ca2+. Although its physiological function is unknown, serum levels of CRP are elevated in a wide variety of acute and chronic inflammatory conditions. These conditions include most bacterial and some viral infections, rheumatic fever, rheumatoid arthritis, and many collagen diseases. CRP serum levels are also valuable in the detection and evaluation of tissue injury, acute myocardial infarction, transplant rejection, and several malignant disorders.

A discussion of the role of CRP as a marker for cardiovascular disease is available as a three part newsletter prepared by Scripps Laboratories. For further details refer to the Literature page. 

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